"The diagnosis of the invasion of measles from a study of the exanthema as it appears on the buccal mucous membrane". "Propagation in tissue culture of cytopathogenic agents from patients with measles". "Classic Paper: The diagnosis of the invasion of measles from a study of the exanthema as it appears on the buccal mucous membrane". "Infectious Diseases." Pathologic Basis of Disease. ^ Tierney LM, Wang KC (February 2006).^ a b Steichen O, Dautheville S (2009).Koplik was aware of Filatov's work, thought his evidence insufficient and rejected his claim for priority. Flindt in 1879, and the Russian Nil Filatov (1847-1902) in 1895, had observed equivalent phenomena. Before Koplik, the German internist Carl Jakob Adolf Christian Gerhardt (1833-1902) in 1874, the Danish physician N. Some authors ascribe the first written description of these spots to Reubold, Würzburg 1854, and others to Johann Andreas Murray (1740-1791). An anonymous reviewer of Koplik's The Diseases of Infancy and Childhood refers to the illustration as "the now famous coloured plate". He published two further papers on the spots, including one with a colour illustration. Koplik's spots are named after Henry Koplik (1858-1927), an American pediatrician who published a short description of them in 1896, emphasising their appearance before the skin rash and their value in the differential diagnosis of diseases with which measles might be mistaken. Enders and Thomas Peebles, who first isolated the measles virus, were careful to collect their samples from patients showing Koplik's spots. Their appearance, in context of a diagnosed case, before they reach maximum infectivity, permits isolation of the contacts and greatly aids control of this highly infectious disease. As well as their diagnostic significance they are important in the control of outbreaks. They are described as appearing like "grains of salt on a reddish background", and often fade as the maculopapular rash develops. The textbook description of Koplik spots is ulcerated mucosal lesions marked by necrosis, neutrophilic exudate, and neovascularization. They are characterized as clustered, white lesions on the buccal mucosa (opposite the lower 1st & 2nd molars) and are pathognomonic for measles. Koplik's spots (also Koplik's sign) are a prodromic viral enanthem of measles manifesting two to three days before the measles rash itself. I can't pin him down to a definite date for his arrival. To make (someone) give a definite answer, statement, opinion or promise. He has dozens of pin-ups in his room ( also adjective) a pin-up girl. a picture of an attractive girl (or man), often pinned on a wall. Dictionary of Military and Associated Terms.
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